Budding off from the broader developmental biology and stem cell research fields, cellular reprogramming is now established as a prominent discipline in its own right. Direct cell reprogramming is defined as the cell fate conversion of a somatic cell toward another identity without a pluripotent intermediate state. In addition to the opportunity for mechanistic dissection of lineage commitment in human cells, the field offer the promise of diverse applications such as for disease modeling, cell replacement therapy, regenerative medicine, and immunotherapy that have recently spurred innovation and out of the box thinking to unleash the potential of cellular plasticity.

中文翻译：

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直接细胞重编程的过去、现在和未来

从更广泛的发育生物学和干细胞研究领域崭露头角，细胞重编程现在已成为一门突出的学科。直接细胞重编程被定义为体细胞在没有多能中间状态的情况下向另一个身份转变的细胞命运。除了对人类细胞谱系进行机械解剖的机会外，该领域还提供了多种应用的希望，例如疾病建模、细胞替代疗法、再生医学和免疫疗法，这些最近刺激了创新和开箱即用的思考释放细胞可塑性的潜力。