The association of overweight/obesity, and central obesity with thiocyanate (SCN), perchlorate (CIO), and nitrate (NO) in childhood and adolescence is unclear. Therefore, this study aimed to explore this association in 4447 participants comprising children and adolescents (aged 6–19 years) using data from the United States National Health and Nutrition Examination Survey 2005–2016. SCN level was positively associated with overweight/obesity in both children and adolescents, while CIO level was negatively associated with overweight/obesity only in children; however, no significant association was found for NO level. Similar associations were found between SCN level and central obesity. Thus, our results suggest that SCN exposure was associated with overweight/obesity and central obesity in both children and adolescents, while a negative association was observed for CIO in children. Strategies to monitor the exposure levels and the mechanisms underlying the relationship between exposure and the weight parameters are recommended.

中文翻译：

---

使用 2005-2016 年国家健康和营养检查调查 (NHANES) 的数据，美国儿童和青少年接触高氯酸盐、硝酸盐和硫氰酸盐的环境与超重/肥胖和向心性肥胖之间的关联

儿童和青春期超重/肥胖和向心性肥胖与硫氰酸盐 (SCN)、高氯酸盐 (CIO) 和硝酸盐 (NO) 的关联尚不清楚。因此，本研究旨在使用 2005-2016 年美国国家健康和营养检查调查的数据，在 4447 名包括儿童和青少年（6-19 岁）的参与者中探索这种关联。SCN 水平与儿童和青少年的超重/肥胖呈正相关，而 CIO 水平仅与儿童的超重/肥胖呈负相关；然而，没有发现与 NO 水平有显着关联。在 SCN 水平和向心性肥胖之间发现了类似的关联。因此，我们的结果表明，SCN 暴露与儿童和青少年的超重/肥胖和向心性肥胖有关，而在儿童中观察到 CIO 呈负相关。推荐了监测暴露水平的策略以及暴露与体重参数之间关系的潜在机制。