A definition of normal human fetal and early postnatal ovarian development is critical to the ability to accurately diagnose the presence or absence of functional ovarian tissue in clinical specimens. Through assembling an extensive histologic and immunohistochemical developmental ontogeny of human ovarian specimens from 8 weeks of gestation through 16 years of postnatal, we present a comprehensive immunohistochemical mapping of normal protein expression patterns in the early fetal through post-pubertal human ovary and detail a specific expression-based definition of the early stages of follicular development. Normal fetal and postnatal ovarian tissue is defined by the presence of follicular structures and characteristic immunohistochemical staining patterns, including granulosa cells expressing Forkhead Box Protein L2 (FOXL2). However, the current standard array of immunohistochemical markers poorly defines ovarian stromal tissue, and additional work is needed to identify new markers to advance our ability to accurately identify ovarian stromal components in gonadal specimens from patients with disorders of sexual differentiation.

正常人类胎儿和产后早期卵巢发育的定义对于准确诊断临床标本中是否存在功能性卵巢组织的能力至关重要。通过对从妊娠 8 周到产后 16 年的人类卵巢标本进行广泛的组织学和免疫组织化学发育个体发育，我们提出了早期胎儿到青春期后人类卵巢正常蛋白表达模式的综合免疫组织化学图谱，并详细说明了特定的表达- 基于卵泡发育早期阶段的定义。正常胎儿和产后卵巢组织的定义是存在滤泡结构和特征性免疫组织化学染色模式，包括表达叉头盒蛋白 L2 (FOXL2) 的颗粒细胞。然而，