BACKGROUND:Coronary arteries disease has been reported as one of the principal roots of deaths worldwide. OBJECTIVE:The aim of this study is to analyze the multiphase pulsatile blood flow in the left coronary artery tree with stenosis. METHODS:The 3D left coronary artery model was reconstructed using 2D computerized tomography (CT) scan images. The Red Blood Cell (RBC) and varying hemodynamic parameters for single and multiphase blood flow conditions were analyzed. RESULTS:Results asserted that the multiphase blood flow modeling has a maximum velocity of 1.017 m/s and1.339 m/s at the stenosed region during the systolic and diastolic phases respectively. The increase in Wall Shear Stress (WSS) observed at the stenosed region during the diastole phase as compared during the systolic phase. It was also observed that the highest Oscillatory Shear Index (OSI) regions are found in the downstream area of stenosis and across the bifurcations. The increase in RBCs velocity from 0.45 m/s to 0.6 m/s across the stenosis was also noticed. CONCLUSION:The computational multiphase blood flow analysis improves the understanding and accuracy of the complex flow conditions of blood elements (RBC and Plasma) and provides the progression of the disease development in the coronary arteries. This study helps to enhance the diagnosis of the blocked (stenosed) arteries more precisely compared to the single-phase blood flow modeling.

中文翻译：

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使用图像处理技术可视化患者特定狭窄左冠状动脉中单相血流的多相搏动血液

背景：据报道，冠状动脉疾病是全世界死亡的主要原因之一。目的：本研究的目的是分析狭窄的左冠状动脉树中的多相脉动血流。方法：使用 2D 计算机断层扫描 (CT) 扫描图像重建 3D 左冠状动脉模型。分析了单相和多相血流条件下的红细胞 (RBC) 和不同的血液动力学参数。结果：结果表明，多相血流模型在收缩期和舒张期的狭窄区域分别具有 1.017 m/s 和 1.339 m/s 的最大速度。与收缩期相比，舒张期狭窄区域观察到的壁面剪切应力 (WSS) 增加。还观察到最高的振荡剪切指数 (OSI) 区域位于狭窄的下游区域和分叉处。还注意到红细胞速度在狭窄处从 0.45 m/s 增加到 0.6 m/s。结论：计算多相血流分析提高了对血液成分（红细胞和血浆）复杂流动条件的理解和准确性，并提供了冠状动脉疾病发展的进展。与单相血流模型相比，这项研究有助于更准确地增强对阻塞（狭窄）动脉的诊断。计算性多相血流分析提高了对血液成分（红细胞和血浆）复杂流动条件的理解和准确性，并提供了冠状动脉疾病发展的进展。与单相血流模型相比，这项研究有助于更准确地增强对阻塞（狭窄）动脉的诊断。计算性多相血流分析提高了对血液元素（红细胞和血浆）复杂流动条件的理解和准确性，并提供了冠状动脉疾病发展的进展。与单相血流模型相比，这项研究有助于更准确地增强对阻塞（狭窄）动脉的诊断。