BACKGROUND:The bulk metallic glass (BMG), Pd79Ag3.5P6Si9.5Ge2, has a high fracture toughness and has been found to accommodate post-yield stress, unlike most other BMG. Moreover, due to its greater noble gas composition it has a intrinsic corrosion resistance, ideal for dental and orthopedic implants. OBJECTIVE:This present study aimed to evaluate the in vivo application of Pd79Ag3.5P6Si9.5Ge2 in a large translational sheep model to assess its efficacy to be utilized as an endosteal device. METHODS:Twelve implants in the form of cylindrical rods (3 mm in diameter) were produced through rapid quenching. Each sheep (n = 12) received one osteotomy in the mandibular region using rotary instrumentation, which was subsequently filled with Pd79Ag3.5P6Si9.5Ge2. After 6- and 24-weeks the animals were euthanized, and samples collected en bloc to conduct histomorphometric analysis. The level/degrees of osseointegration were assessed through bone-to-implant contact (BIC). RESULTS:Favorable BIC was observed with fibrous connective tissue layers at both 6- and 24-weeks. Bone along with interfacial remodeling was observed in proximity with the metallic glass surface at 6 weeks with higher degrees of bone organization being observed at the later healing time, 24 weeks. CONCLUSIONS:The introduced BMG revealed potential to serve as an alternative biomaterial to commonly used Ti alloys given its unique combination of toughness and strength.

中文翻译：

---

评估 Pd 基大块金属玻璃生物相容性的体内临床前研究

背景：大块金属玻璃 (BMG) Pd79Ag3.5P6Si9.5Ge2 具有高断裂韧性，与大多数其他 BMG 不同，已被发现可以适应屈服后应力。此外，由于其惰性气体成分较多，它具有固有的耐腐蚀性，是牙科和骨科植入物的理想选择。目的：本研究旨在评估 Pd79Ag3.5P6Si9.5Ge2 在大型平移绵羊模型中的体内应用，以评估其用作骨内膜装置的功效。方法：通过快速淬火生产 12 个圆柱形杆状（直径 3 mm）的植入物。每只绵羊 (n = 12) 使用旋转仪器在下颌骨区域接受一次截骨术，随后用 Pd79Ag3.5P6Si9.5Ge2 填充。6 周和 24 周后，动物被安乐死，和整体收集的样本进行组织形态学分析。通过骨与种植体接触 (BIC) 评估骨整合的水平/程度。结果：在 6 周和 24 周时，纤维结缔组织层均观察到良好的 BIC。在 6 周时观察到金属玻璃表面附近的骨和界面重塑，在 24 周的后期愈合时间观察到更高程度的骨组织。结论：鉴于其独特的韧性和强度组合，引入的 BMG 显示出作为常用钛合金替代生物材料的潜力。在 6 周时观察到金属玻璃表面附近的骨和界面重塑，在 24 周的后期愈合时间观察到更高程度的骨组织。结论：鉴于其独特的韧性和强度组合，引入的 BMG 显示出作为常用钛合金替代生物材料的潜力。在 6 周时观察到金属玻璃表面附近的骨和界面重塑，在 24 周的后期愈合时间观察到更高程度的骨组织。结论：鉴于其独特的韧性和强度组合，引入的 BMG 显示出作为常用钛合金替代生物材料的潜力。