The serine/threonine phosphatase calcineurin complex has been considered a prospective target for developing novel drugs due to its importance in fungal growth, virulence, and stress responses in pathogenic fungi. Therefore, two well-known immunosuppressants, FK506 and cyclosporine A were successfully identified to inhibit calcineurin by combining with FK506-binding protein 12 and cyclophilin A, respectively. However, these drugs are immunosuppressive and may exhibit serious side effects. There is a growing number of literatures reported on further exploring functions of the calcineurin complex as promising antifungal targets. In general, the majority of the calcineurin complex structures are conserved but some functions are species-specific. Nevertheless, there still have a lot of functional motifs in the calcineurin complex that are unexplored. Therefore, further investigation and experimentation into the calcineurin complex are strongly required. This review not only has summarized previous findings but also explored bioinformatics analysis along with structural models of the calcineurin complex for finding fungal-specific regions as potential targets, laying the groundwork for future research into new therapeutics.

丝氨酸/苏氨酸磷酸酶钙调神经磷酸酶复合物因其在病原真菌的真菌生长、毒力和应激反应中的重要性而被认为是开发新型药物的潜在靶点。因此，通过与 FK506 结合蛋白 12 和亲环蛋白 A 的结合，成功鉴定出两种众所周知的免疫抑制剂 FK506 和环孢素 A 可抑制钙调神经磷酸酶。然而，这些药物具有免疫抑制作用，可能会出现严重的副作用。越来越多的文献报道了进一步探索钙调神经磷酸酶复合物作为有希望的抗真菌靶点的功能。一般来说，大多数钙调神经磷酸酶复合物结构是保守的，但有些功能是物种特异性的。尽管如此，钙调神经磷酸酶复合物中仍有许多功能基序未被探索。因此，强烈需要对钙调神经磷酸酶复合物进行进一步的研究和实验。这篇综述不仅总结了以前的研究结果，还探索了生物信息学分析以及钙调神经磷酸酶复合物的结构模型，以寻找真菌特异性区域作为潜在靶点，为未来研究新疗法奠定基础。