ABSTRACT

Hypomelanosis of Ito (HI) is a neurocutaneous disorder associated with central nervous system abnormalities, including speech delay and intellectual disability. The long term neuropsychological and social characteristics of these children are unknown. Neuropsychological observations and parental reports were obtained yearly on a child with HI from ages 7 to 18 years. Serial measures of intelligence revealed stable verbal and perceptual reasoning scores with later improvements in working memory and processing speed performance. Speech articulation improved at age 12, as did the speed of right-hand finger tapping. Improved social integration occurred, but anxiety persisted throughout this developmental period.

摘要

伊藤色素沉着症 (HI) 是一种与中枢神经系统异常相关的神经皮肤疾病，包括言语延迟和智力障碍。这些儿童的长期神经心理和社会特征尚不清楚。每年对一名 7 至 18 岁的 HI 儿童进行神经心理学观察和父母报告。智力的一系列测量显示稳定的语言和感知推理分数，随后在工作记忆和处理速度性能方面有所改善。12 岁时发音清晰度有所提高，右手手指敲击的速度也有所提高。社会融合得到改善，但焦虑在整个发育时期一直存在。