Over the past 30 years, numerous neuroscientific studies involving both human and rodent subjects have investigated the brain regions and networks supporting path integration and sought to identify the underlying neural mechanisms. Although these studies contributed to an increased understanding of path integration, a full picture of the brain mechanisms supporting path integration remains wanting. Hence, the current review was conducted with the aim of presenting an overview of the most notable neuroscientific studies on visual path integration in humans, identifying the commonalities and discrepancies in their findings, and introducing fresh ideas for future research. Specifically, this review focused on studies performed with virtual simulations of the triangle/path completion task and addressed whether or not the hippocampal formation is necessary for human path integration. Based on findings that supported and contradicted the involvement of the hippocampal formation in path integration, it was proposed that the use of different path integration strategies may determine the extent to which the hippocampus and entorhinal cortex are engaged during human path integration. To this end, recent studies investigating the impact of different path integration strategies on behavioral performance and functional brain activity were discussed. Methodological concerns were raised with feasible recommendations for improving the experimental design of future strategy-focused human path integration studies, which can cover cognitive neuroscience research on age-related differences in the role of the hippocampal formation in path integration and Bayesian modeling of the interaction between landmark and self-motion cues. The practical value of investigating different path integration strategies was also discussed briefly from a biomedical perspective. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

中文翻译：

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人类视觉路径整合的神经科学研究：从战略角度对路径完成范式和海马结构的潜在作用进行专题回顾。

在过去的 30 年中，涉及人类和啮齿动物受试者的大量神经科学研究调查了支持路径整合的大脑区域和网络，并试图确定潜在的神经机制。尽管这些研究有助于加深对路径整合的理解，但仍然缺乏支持路径整合的大脑机制的全貌。因此，本次审查的目的是概述关于人类视觉路径整合的最著名的神经科学研究，确定其研究结果的共性和差异，并为未来的研究引入新的思路。具体来说，这篇综述侧重于通过三角形/路径完成任务的虚拟模拟进行的研究，并讨论了海马结构是否是人类路径整合所必需的。基于支持和反驳海马体结构参与路径整合的发现，有人提出使用不同的路径整合策略可能决定海马体和内嗅皮质在人类路径整合过程中的参与程度。为此，讨论了最近调查不同路径整合策略对行为表现和功能性大脑活动的影响的研究。方法论问题提出了可行的建议，以改进未来以战略为中心的人类路径整合研究的实验设计，它可以涵盖关于海马结构在路径整合中作用的年龄相关差异的认知神经科学研究，以及地标和自我运动线索之间相互作用的贝叶斯建模。还从生物医学的角度简要讨论了研究不同路径整合策略的实用价值。（PsycInfo 数据库记录 (c) 2022 APA，保留所有权利）。