Neural interfaces are fundamental tools for transmitting information from the nervous system. Research on the immune response of an invasive neural interface is a field that requires continuous effort. Various efforts have been made to overcome or minimize limitations through modifying the designs and materials of neural interfaces, modifying surface characteristics, and adding functions to them. In this study, we demonstrate microfluidic channels with crater-shaped structures fabricated using parylene-C membranes for fluid delivery from the perspective of theory, design, and simulation. The simulation results indicated that the fluid flow depended on the size of the outlet and the alignment of microstructures inside the fluidic channel. All the results can be used to support the design of microfluidic channels made by membranes for drug delivery.

中文翻译：

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基于微流控柔性互连电缆的化学输送神经接口的设计与仿真

神经接口是从神经系统传输信息的基本工具。侵入性神经接口的免疫反应研究是一个需要不断努力的领域。通过修改神经接口的设计和材料、修改表面特性并为其添加功能，已经做出各种努力来克服或最小化限制。在这项研究中，我们从理论、设计和模拟的角度展示了使用聚对二甲苯-C 膜制造的用于流体输送的具有火山口形结构的微流体通道。模拟结果表明，流体流动取决于出口的大小和流体通道内微结构的排列。所有的结果都可以用来支持由膜制成的用于药物输送的微流体通道的设计。