The development of innovative sensors for the detection of analytes at extremely low concentrations with great sensitivity and selectivity has been a major focus of this study. The electrochemical activity of chlorpheniramine maleate (CPRM) in the presence of a graphene modified GCE has been investigated. Cyclic voltammograms (CV) have been obtained in the linear dynamic range 3.5- 156 μM while the optimum pH range and the maximum peak current (IPa) have been measured at pH 7.3. The process on the electrode's surface, diffusion regulated, heterogeneous rate constant, charge transfer coefficient, and the number of electrons transferred among the physicochemical properties have been obtained. Differential pulse voltammetry (DPV) of CPRM at the modified has electrode revealed a good linear calibration curve with a linear range of 10 to 60 μM and limit of detection of 0.062 μM. The suggested sensor has been fabricated and utilized to determine CPRM in medicines as well as serum samples.

中文翻译：

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石墨烯纳米片的合成与表征，用于使用改性玻碳电极对马来酸扑尔敏药物进行电化学定量

开发用于检测极低浓度分析物且具有高灵敏度和选择性的创新传感器一直是本研究的重点。已经研究了在石墨烯修饰的 GCE 存在下马来酸扑尔敏 (CPRM) 的电化学活性。在 3.5-156 μM 的线性动态范围内获得了循环伏安图 (CV)，而在 pH 7.3 下测量了最佳 pH 范围和最大峰值电流 (IPa)。获得了电极表面过程、扩散调节、异相速率常数、电荷转移系数、转移电子数之间的理化性质。CPRM 在改性电极上的差分脉冲伏安法 (DPV) 显示出良好的线性校准曲线，线性范围为 10 至 60 μM，检测限为 0.062 μM。建议的传感器已被制造并用于确定药物和血清样品中的 CPRM。