The hydrophobic force is one of the most dominant factors in protein folding. A protein becomes functional only when it achieves its three-dimensional structure and stability upon folding. For a better understanding of the hydrophobic effects and their function in protein folding, quantitative measurement of the hydrophobicity of amino acid side chains is crucial. Spike protein is the primary structural protein in SARS-CoV-2 and SARS-CoV. This study explores how protein sequences in SARS-CoV-2 and SARS-CoV spike proteins encode hydrophobic interactions. Computational tools/techniques have been utilized to investigate the protein sequences of the spike proteins of SARS-CoV-2 and SARS-CoV. Investigations provided an estimate of hydrophobic distribution and its relative strength, indicating a hydrophobic pattern. Analysis of the spike protein's hydrophobic profile may help identify and treat the virus-caused disease; additionally, it can give an insight into the transmissibility and pathogenicity of the virus.

疏水力是蛋白质折叠中最主要的因素之一。只有当蛋白质在折叠时达到其三维结构和稳定性时，它才具有功能。为了更好地了解疏水效应及其在蛋白质折叠中的功能，氨基酸侧链疏水性的定量测量至关重要。刺突蛋白是 SARS-CoV-2 和 SARS-CoV 的主要结构蛋白。本研究探讨了 SARS-CoV-2 和 SARS-CoV 刺突蛋白中的蛋白质序列如何编码疏水相互作用。计算工具/技术已被用于研究 SARS-CoV-2 和 SARS-CoV 刺突蛋白的蛋白质序列。调查提供了疏水分布及其相对强度的估计，表明疏水模式。刺突蛋白分析' 其疏水特性可能有助于识别和治疗病毒引起的疾病；此外，它还可以深入了解病毒的传播性和致病性。