Hyperthermia is an additional treatment method to radiation therapy/chemotherapy, which increases the survival rate of patients without side effects. Nowadays, Auroshell nanoparticles have attracted much attention due to their precise control over heat use for medical purposes. In this research, iron/gold Auroshell nanoparticles were synthesised using green nanotechnology approach. Auroshell gold@hematite nanoparticles were synthesised and characterised with rosemary extract in one step and the green synthesised nanoparticles were characterised by X-ray powder diffraction, SEM, high-resolution transmission electron microscopy, and X-ray photoelectron spectroscopy analysis. Cytotoxicity of Auroshell iron@gold nanoparticles against normal HUVEC cells and glioblastoma cancer cells was evaluated by 2,5-diphenyl-2H-tetrazolium bromide method, water bath hyperthermia, and combined method of water bath hyperthermia and nano-therapy. Auroshell gold@hematite nanoparticles with minimal toxicity are safe against normal cells. The gold shell around the magnetic core of magnetite caused the environmental and cellular biocompatibility of these Auroshell nanoparticles. These magnetic nanoparticles with targeted control and transfer to the tumour tissue led to uniform heating of malignant tumours as the most efficient therapeutic agent.

中文翻译：

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基于微量元素的 Auroshell gold@hematite 纳米结构：绿色合成及其热疗。

热疗是放射疗法/化学疗法之外的一种额外治疗方法，可提高患者的生存率且无副作用。如今，Auroshell 纳米颗粒因其对医疗用热的精确控制而备受关注。在这项研究中，铁/金 Auroshell 纳米颗粒是使用绿色纳米技术方法合成的。Auroshell gold@hematite 纳米颗粒与迷迭香提取物一步合成并表征，绿色合成纳米颗粒通过 X 射线粉末衍射、SEM、高分辨率透射电子显微镜和 X 射线光电子能谱分析进行表征。Auroshell iron@gold 纳米粒子对正常 HUVEC 细胞和胶质母细胞瘤癌细胞的细胞毒性通过 2,5-二苯基-2H-四唑溴化物法进行评估，水浴热疗，水浴热疗与纳米疗法相结合的方法。毒性极小的 Auroshell gold@hematite 纳米粒子对正常细胞是安全的。磁铁矿磁芯周围的金壳导致了这些 Auroshell 纳米粒子的环境和细胞生物相容性。这些具有靶向控制和转移到肿瘤组织的磁性纳米颗粒导致恶性肿瘤的均匀加热，成为最有效的治疗剂。