3-D printers are widely used. Based on previous findings, we hypothesized that their emissions could enhance allergen responsiveness and reduce lung diffusing capacity. Using a cross-over design, 28 young subjects with seasonal allergic rhinitis were exposed to 3-D printer emissions, either from polylactic acid (PLA) or from acrylonitrile butadiene styrene copolymer (ABS), for 2 h each. Ninety minutes later, nasal allergen challenges were performed, with secretions sampled after 1.5 h. Besides nasal functional and inflammatory responses, assessments included diffusing capacity. There was also an inclusion day without exposure. The exposures elicited slight reductions in lung diffusing capacity for inhaled nitric oxide (DL_NO) that were similar for PLA and ABS. Rhinomanometry showed the same allergen responses after both exposures. In nasal secretions, concentrations of interleukin 6 and tumor necrosis factor were slightly reduced after ABS exposure versus inclusion day, while that of interleukin 5 was slightly increased after PLA exposure versus inclusion.

中文翻译：

---

实验性暴露于 3-D 打印机排放物对季节性过敏性鼻炎患者鼻腔过敏原反应和吸入一氧化碳/一氧化氮的肺扩散能力的影响

3D打印机被广泛使用。根据之前的发现，我们假设它们的排放物可以增强过敏原反应能力并降低肺扩散能力。使用交叉设计，将 28 名患有季节性过敏性鼻炎的年轻受试者暴露于聚乳酸 (PLA) 或丙烯腈丁二烯苯乙烯共聚物 (ABS) 的 3D 打印机排放物中，每人 2 小时。90 分钟后，进行了鼻过敏原挑战，1.5 小时后对分泌物进行了取样。除了鼻功能和炎症反应外，评估还包括扩散能力。还有一个没有曝光的包容日。暴露引起吸入一氧化氮的肺弥散能力略有下降（DL _NO) 与 PLA 和 ABS 相似。两次接触后，鼻腔测压法显示出相同的过敏原反应。在鼻腔分泌物中，白细胞介素 6 和肿瘤坏死因子的浓度在 ABS 暴露后与包含日相比略有降低，而白细胞介素 5 的浓度在 PLA 暴露后与包含日相比略有增加。