Introduction: Pediatric bipolar disorder (PBD) is a severe psychiatric illness diagnosed before the age of 18, which is associated with extreme shifts in mood characterized by manic and depressive episodes. In 2005, AACAP published algorithms to guide pharmacological treatment of manic/mixed episodes associated with PBD. At that time, lithium was the only Food and Drug Administration (FDA)-approved treatment for pediatric bipolar manic/mixed episodes. The goal of this article is to review evidence that has emerged since the AACAP algorithm in 2005.

中文翻译：

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小儿双相情感障碍躁狂/混合和抑郁发作的精神药理学治疗算法

简介：小儿双相情感障碍 (PBD) 是一种严重的精神疾病，诊断年龄在 18 岁之前，与以躁狂和抑郁发作为特征的极端情绪变化有关。2005 年，AACAP 发布了指导与 PBD 相关的躁狂/混合发作的药物治疗的算法。当时，锂是唯一获得食品和药物管理局 (FDA) 批准的治疗儿科双相躁狂/混合发作的药物。本文的目的是回顾自 2005 年 AACAP 算法以来出现的证据。