Background Inadequate weight gain could indicate clinical deterioration in infants and children living with HIV (CLHIV). The World Health Organization's (WHO) weight-for-age z-score (WAZ) growth standards and reference charts are currently used in South Africa to assess weight gain in CLHIV on antiretroviral treatment (ART). Objectives To assess weight gain patterns of infants and children initiated on ART and to compare weight gain patterns between the WHO WAZ growth standards and population-specific curves constructed from data of CLHIV on ART. Method A quantitative, retrospective and descriptive-comparative design was used. The weight gain patterns of 98 infants and children from birth to 10 years old during the 24-month period following ART initiation were recorded and assessed using two different growth charts. Results The children's rate of weight and length gain improved significantly over 24 months since ART initiation, but complete catch-up growth was never achieved. Most (69%) of the children had increased weight gain according to the WAZ growth standard and reference charts versus only 16% according to the HIV-specific weight gain curves. Conclusion Antiretroviral treatment improved weight and height gain in CLHIV, but the interpretations of weight gain differed significantly between the WHO chart and HIV-specific weight gain curves. Population- and treatment-specific references could improve weight monitoring in CLHIV and assist in the timeous identification of malnutrition.

中文翻译：

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接受抗逆转录病毒治疗的儿童从出生到 10 岁体重增加。

背景 体重增加不足可能表明感染艾滋病毒 (CLHIV) 的婴儿和儿童的临床状况恶化。南非目前使用世界卫生组织 (WHO) 的年龄别体重 z 分数 (WAZ) 生长标准和参考图表来评估 CLHIV 接受抗逆转录病毒治疗 (ART) 后的体重增加。目标 评估开始接受 ART 治疗的婴儿和儿童的体重增加模式，并比较 WHO WAZ 生长标准与根据 CLHIV 数据构建的特定人群曲线之间的体重增加模式。方法 采用定量、回顾性和描述性比较设计。在 ART 开始后的 24 个月期间，记录了 98 名婴儿和儿童从出生到 10 岁的体重增加模式，并使用两种不同的生长图表进行了评估。结果 孩子们的 自 ART 开始以来的 24 个月内，她的体重和身长增加率显着提高，但从未实现完全追赶增长。根据 WAZ 生长标准和参考图表，大多数 (69%) 儿童的体重增加增加，而根据 HIV 特定体重增加曲线，只有 16% 的儿童增加了体重。结论 抗逆转录病毒治疗改善了 CLHIV 的体重和身高增加，但 WHO 图表和 HIV 特异性体重增加曲线对体重增加的解释存在显着差异。特定人群和特定治疗的参考可以改善 CLHIV 的体重监测，并有助于及时识别营养不良。根据 WAZ 生长标准和参考图表，大多数 (69%) 儿童的体重增加增加，而根据 HIV 特定体重增加曲线，只有 16% 的儿童增加了体重。结论 抗逆转录病毒治疗改善了 CLHIV 的体重和身高增加，但 WHO 图表和 HIV 特异性体重增加曲线对体重增加的解释存在显着差异。特定人群和特定治疗的参考可以改善 CLHIV 的体重监测，并有助于及时识别营养不良。根据 WAZ 生长标准和参考图表，大多数 (69%) 儿童的体重增加增加，而根据 HIV 特定体重增加曲线，只有 16% 的儿童增加了体重。结论 抗逆转录病毒治疗改善了 CLHIV 的体重和身高增加，但 WHO 图表和 HIV 特异性体重增加曲线对体重增加的解释存在显着差异。特定人群和特定治疗的参考可以改善 CLHIV 的体重监测，并有助于及时识别营养不良。