We report two cases of dolutegravir (DTG) resistance in highly treatment experienced patients. Monitoring for treatment failure and adherence support is important in highly treatment experienced patients taking DTG. What this study adds Dolutegravir is the mainstay of HIV treatment programmes and emergence of drug resistance to DTG is of public health relevance.

中文翻译：

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来自津巴布韦的未接受过整合酶治疗的患者出现多替拉韦耐药性。

我们报告了两例治疗经验丰富的患者出现多替拉韦 (DTG) 耐药的情况。治疗失败的监测和依从性支持对于服用 DTG 的高度治疗经验的患者很重要。这项研究补充说，Dolutegravir 是 HIV 治疗计划的中流砥柱，对 DTG 耐药性的出现与公共卫生相关。