Transcriptional enhanced associate domain (TEAD) transcription factors play important roles in embryonic stem cell (ESC) renewal and differentiation. Four TEAD transcription factors (Tead1, Tead2, Tead3 and Tead4) and their various splice variants have been discovered in mice, but the expression pattern of them during pluripotency state transition is unclear. Here, we investigated the expression of TEADs and their splice variants in mouse ESCs at different pluripotent/differentiating states and adult mouse tissues. Our results preliminarily revealed the diversity and heterogeneity of TEAD family, which is helpful for understanding their overlapping and distinctive functions. Furthermore, a novel splice variant of Tead1 was identified and named Tead1 isoform 4.

转录增强关联域（TEAD）转录因子在胚胎干细胞（ESC）更新和分化中发挥重要作用。在小鼠体内发现了四种TEAD转录因子（Tead1、Tead2、Tead3和Tead4）及其各种剪接变体，但它们在多能状态转变过程中的表达模式尚不清楚。在这里，我们研究了 TEAD 及其剪接变体在不同多能/分化状态的小鼠 ESC 和成年小鼠组织中的表达。我们的结果初步揭示了TEAD家族的多样性和异质性，这有助于理解它们重叠和独特的功能。此外，还鉴定出 Tead1 的一种新剪接变体，并将其命名为 Tead1 同工型 4。