Objectives 

The present review describes stroke pathophysiology in brief and discusses the spectrum of available treatments with different promising interventions that are in clinical settings or are in clinical trials.

Methods 

Relevant articles were searched using Google Scholar, Cochrane Library, and PubMed. Keywords for the search included ischemic stroke, mechanisms, stroke interventions, clinical trials, and stem cell therapy.

Results and Conclusion 

Stroke accounts to a high burden of mortality and morbidity around the globe. Time is an important factor in treating stroke. Treatment options are limited; however, agents with considerable efficacy and tolerability are being continuously explored. With the advances in stroke interventions, new therapies are being formulated with a hope that these may aid the ongoing protective and reparative processes. Such therapies may have an extended therapeutic time window in hours, days, weeks, or longer and may have the advantage to be accessible by a majority of the patients.

中文翻译：

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中风干预的药理学策略：病理生理相关性和临床试验的评估

目标 

本综述简要描述了中风的病理生理学，并讨论了临床环境或临床试验中具有不同前景的干预措施的可用治疗范围。

方法 

使用 Google Scholar、Cochrane Library 和 PubMed 搜索相关文章。搜索关键词包括缺血性中风、机制、中风干预、临床试验和干细胞治疗。

结果与结论 

中风是全球死亡率和发病率的高负担。时间是治疗中风的重要因素。治疗选择有限；然而，正在不断探索具有相当疗效和耐受性的药物。随着中风干预措施的进步，正在制定新疗法，希望这些疗法可以帮助正在进行的保护和修复过程。此类疗法可能具有数小时、数天、数周或更长的延长治疗时间窗，并且可能具有大多数患者可获得的优势。