Oral squamous cell carcinoma (OSCC) is one of the most common lip and oral cavity cancer types. It requires early detection via various medical technologies to improve the survival rate. While most detection techniques for OSCC require testing in a centralized lab to confirm cancer type, a point of care detection technique is preferred for on-site use and quick result readout. The modular biological sensor utilizing transistor-based technology has been leveraged for testing CIP2A, and optimal transistor gate voltage and load resistance for sensing setup was investigated. Sensitivities of 1 × 10⁻¹⁵ g/ml have been obtained for both detections of pure CIP2A protein and HeLa cell lysate using identical test conditions via serial dilution. The superior time-saving and high accuracy testing provides opportunities for rapid clinical diagnosis in the medical space.

中文翻译：

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使用快速晶体管生物传感器模块对口腔癌进行高灵敏度 CIP2A 检测

口腔鳞状细胞癌（OSCC）是最常见的唇癌和口腔癌类型之一。需要通过各种医疗技术进行早期发现，以提高生存率。虽然大多数 OSCC 检测技术需要在集中实验室进行测试来确认癌症类型，但护理点检测技术更适合现场使用和快速结果读出。利用基于晶体管技术的模块化生物传感器已用于测试 CIP2A，并研究了用于传感设置的最佳晶体管栅极电压和负载电阻。 使用相同的测试条件，通过连续稀释，对纯CIP2A蛋白和HeLa细胞裂解物的检测都获得了1×10 ^{-15 g/ml的灵敏度。}卓越的省时和高精度测试为医疗领域的快速临床诊断提供了机会。