Many diseases affect the autonomous nervous system and the central nervous system simultaneously, for example Parkinson's disease or irritable bowel syndrome. To study neurophysiologic interactions between the intestinal electrical activity and the electroencephalography (EEG) pattern of the brain, we combined intestinal electrical stimulation (IES) and non-invasive telemetric full-band DC EEG recordings in an acute pig-model. Intestinal motility was monitored with accelerometers. Brain activity was analyzed with regard to network driven phenomena like phase amplitude coupling (PAC) within two time-windows: 1 min after IES (early response) and 3 min after stimulation (late response). Here we present the results for two stimulation sites (small intestine, colon) and two parietal scalp-EEG channels (right and left somatosensory cortex region). Electrical stimulation consisted of a 30 or 130 Hz pulse. In summary, the PAC modulation index at a parietal EEG recording position is decreased after IES. This effect is in line with an inhibitory effect of our IES protocol regarding peristalsis. The surprisingly strong effects of IES on network driven EEG patterns may be translated into new therapeutic techniques and/or diagnostic tools in the future. Furthermore, analytic tools, operating on sparse datasets, may be ideally suited for the integration in implantable intestinal pacemakers as feedback system.

中文翻译：

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脑电图与肠道电刺激的相关性。

许多疾病同时影响自主神经系统和中枢神经系统，例如帕金森病或肠易激综合症。为了研究肠道电活动与大脑脑电图 (EEG) 模式之间的神经生理学相互作用，我们在急性猪模型中结合了肠道电刺激 (IES) 和非侵入性遥测全波段 DC 脑电图记录。用加速度计监测肠蠕动。在两个时间窗口内针对网络驱动现象（如相位振幅耦合 (PAC)）分析大脑活动：IES 后 1 分钟（早期反应）和刺激后 3 分钟（晚期反应）。在这里，我们展示了两个刺激部位（小肠、结肠）和两个顶叶头皮脑电图通道（左右体感皮层区域）的结果。电刺激由 30 或 130 赫兹的脉冲组成。总之，顶叶 EEG 记录位置的 PAC 调制指数在 IES 后降低。这种效果符合我们关于蠕动的 IES 协议的抑制作用。IES 对网络驱动的 EEG 模式的惊人强烈影响可能会在未来转化为新的治疗技术和/或诊断工具。此外，在稀疏数据集上运行的分析工具可能非常适合作为反馈系统集成到植入式肠道起搏器中。IES 对网络驱动的 EEG 模式的惊人强烈影响可能会在未来转化为新的治疗技术和/或诊断工具。此外，在稀疏数据集上运行的分析工具可能非常适合作为反馈系统集成到植入式肠道起搏器中。IES 对网络驱动的 EEG 模式的惊人强烈影响可能会在未来转化为新的治疗技术和/或诊断工具。此外，在稀疏数据集上运行的分析工具可能非常适合作为反馈系统集成到植入式肠道起搏器中。