BACH2 [BTB (broad-complex, tramtrak and bric à brac) and CNC (cap 'n' collar) homolog 2] is known as a transcriptional repressor and broadly functions in regulating immune cell differentiation. Here, we focus on BACH2 function in B cells, where BACH2 was first shown to play an important role in the immune system. In B cells, BACH2 orchestrates the gene regulatory network that promotes class switch and affinity maturation of antibodies and simultaneously represses plasma-cell differentiation. In this context, BACH2 regulates gene expression by modulating chromatin organization, cooperatively with other transcription factors and chromatin regulators, such as IRF4 (interferon regulatory factor 4) and PC4 (positive coactivator 4), respectively. In addition, our recent observation raises the possibility that BACH2 has diverse functions, such as those in gene activation. Since dysfunction of BACH2 leads to the onset of human immune deficiencies, revealing new functions of BACH2 may give a cue to solve how BACH2 contributes to preventing these diseases.

中文翻译：

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探索 BACH2 在获得抗原特异性抗体中的新功能。

BACH2 [BTB（广泛复合物、tramtrak 和 bric à brac）和 CNC（cap 'n' collar）同系物 2] 被称为转录抑制因子，在调节免疫细胞分化方面具有广泛的功能。在这里，我们关注 B 细胞中的 BACH2 功能，其中 BACH2 首次被证明在免疫系统中发挥重要作用。在 B 细胞中，BACH2 协调基因调控网络，促进抗体的类别转换和亲和力成熟，同时抑制浆细胞分化。在这种情况下，BACH2 通过调节染色质组织，与其他转录因子和染色质调节因子（例如 IRF4（干扰素调节因子 4）和 PC4（阳性共激活因子 4））协同作用来调节基因表达。此外，我们最近的观察提出了 BACH2 具有多种功能的可能性，比如基因激活。由于 BACH2 的功能障碍会导致人类免疫缺陷的发生，因此揭示 BACH2 的新功能可能会为解决 BACH2 如何有助于预防这些疾病提供线索。