Data regarding plant extracts with antiaging properties, particularly through the biological process involving telomeres and telomerase, are limited. Thus, this study aimed to investigate the effects of Acanthopanax senticosus extract (ASE) supplementation on leukocyte telomere length (LTL), telomerase, and inflammatory and metabolic markers in adult animal models. A freeze-dried product of ethanol extracts was prepared using a mixture product of stem and root ASE. In a 24-week experiment that included 24-week-old Sprague Dawley male rats, experimental rats (n = 10) were administrated with 7 mg/day of ASE dissolved in saline and control rats (n = 10) with saline. All rats had access to chow and tap water ad libitum. Their LTL and plasma levels of telomerase and inflammatory and metabolic markers were assayed and compared between the two groups. The experimental rats showed significantly longer LTL (p < 0.05) and lower plasma levels of alanine aminotransferase (p < 0.05) and aspartate aminotransferase (p = 0.08) compared with the control. In addition, LTL was correlated with the aforementioned biochemical parameters of liver function test among experimental rats only. No significant differences in plasma levels of telomerase and inflammatory and metabolic markers were observed. These findings indicate that ASE supplementation may attenuate LTL shortening and reduce liver biochemical parameters, indicating its potential antiaging and hepatoprotective effects without any adverse metabolic response.

中文翻译：

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刺五加提取物对成年大鼠模型的潜在抗衰老和保肝作用

关于具有抗衰老特性的植物提取物的数据，特别是通过涉及端粒和端粒酶的生物过程，是有限的。因此，本研究旨在研究刺五加提取物 (ASE) 补充剂对成年动物模型中白细胞端粒长度 (LTL)、端粒酶以及炎症和代谢标志物的影响。使用茎和根ASE的混合产物制备乙醇提取物的冻干产物。在一项包括 24 周大的 Sprague Dawley 雄性大鼠在内的为期 24 周的实验中，实验大鼠 ( n  = 10) 每天服用 7 毫克溶解在盐水中的 ASE，对照组大鼠 ( n  = 10) 服用盐水。所有老鼠都可以随意饮用食物和自来水. 对两组的 LTL 和端粒酶以及炎症和代谢标志物的血浆水平进行了测定和比较。实验大鼠表现出显着更长的 LTL ( p  < 0.05) 和更低的丙氨酸氨基转移酶 ( p  < 0.05) 和天冬氨酸氨基转移酶 ( p = 0.08) 与对照相比。此外，LTL仅与上述实验大鼠肝功能生化指标相关。端粒酶、炎症和代谢标志物的血浆水平没有显着差异。这些发现表明，ASE 补充剂可能会减弱 LTL 缩短并降低肝脏生化参数，表明其潜在的抗衰老和保肝作用而没有任何不良代谢反应。