The aim of this study was to evaluate the clinicopathological significance of autocrine motility factor receptor (AMFR) expression in a variety of human invasive micropapillary carcinomas (IMPC). AMFR expression was compared in 111 samples of a variety of human IMPCs which had intrinsic non-micropapillary components and with 26 cases of control pulmonary adenocarcinoma (CPA, carcinoma without an IMPC component) by immunohistochemistry (IHC). In the 137 cases analysed, AMFR expression was significantly elevated in the IMPC components compared to the non-IMPC components (p = .005) and normal tissues (p < .001). AMFR expression was also higher in the IMPC samples compared to their intrinsic non-IMPC components (p = .0234). Between the 69 cases of lung IMPC and 26 cases of CPA, AMFR expression was notably higher in the IMPC components than in the CPA components (p = .0455). However, there was no significant difference between the non-IMPC components in the lung and the CPA components (p = .4584). Moreover, in breast cancer, elevated AMFR expression was not significantly correlated with mixed type or pure type IMPC (p = .5969) or with age, gender, T stage, or lymph node metastasis (LNM). Between IMPC and CPA of the lung, there was no statistical significance in age, T stage, and LNM, where AMFR expression was higher in IMPC (p = .0071). Thus this study demonstrated that AMFR was overexpressed in a variety of human IMPC components compared with non-micropapillary components. This suggests that AMFR expression is a potential new prognostic indicator for different types of human IMPC, which might thus be a new therapeutic target.

中文翻译：

---

自分泌运动因子受体（AMFR）在人乳腺癌和肺浸润性微乳头状癌中的表达

本研究的目的是评估自分泌运动因子受体（AMFR）在多种人类浸润性微乳头状癌（IMPC）中表达的临床病理意义。通过免疫组织化学 (IHC) 将 AMFR 表达在 111 个具有内在非微乳头成分的人类 IMPC 样本中与 26 例对照肺腺癌（CPA，无 IMPC 成分的癌）样本中进行比较。在分析的 137 个病例中，与非 IMPC 成分 ( p  = .005) 和正常组织 ( p  < .001) 相比，IMPC 成分中的 AMFR 表达显着升高。与其内在的非 IMPC 成分相比，IMPC 样本中的 AMFR 表达也较高 ( p  = .0234)。在 69 例肺 IMPC 病例和 26 例 CPA 病例之间，IMPC 成分中 AMFR 的表达显着高于 CPA 成分 ( p  = .0455)。然而，肺部的非 IMPC 成分和 CPA 成分之间没有显着差异 ( p  = .4584)。此外，在乳腺癌中，AMFR 表达升高与混合型或纯型 IMPC ( p  = .5969) 或年龄、性别、T 分期或淋巴结转移 (LNM) 没有显着相关性。在肺的 IMPC 和 CPA 之间，年龄、T 分期和 LNM 没有统计学意义，其中 IMPC 中 AMFR 表达较高 ( p  = .0071)。因此，这项研究表明，与非微毛细管成分相比，AMFR 在多种人类 IMPC 成分中过度表达。这表明 AMFR 表达是不同类型人类 IMPC 的潜在新预后指标，因此可能成为新的治疗靶点。