Lung cancer is the most common and deadliest type of cancer worldwide. Research concerning lung cancer has made considerable progress in recent decades, but lung cancer remains the leading cause of malignancy-related mortality rate. Mesenchymal stem cells (MSCs) mainly exist in fat, umbilical cord blood, bone marrow, bone, and muscle. MSCs are a primary component of the tumor microenvironment (TME). Recent studies have shown that MSCs have roles in lung cancer-related proliferation, invasion, migration, and angiogenesis, but the underlying mechanisms are poorly understood. Because MSCs can migrate to the TME, there is increasing attention toward the use of MSCs in drugs or gene vectors for cancer treatment. This review summarizes the roles and effects of MSCs in lung cancer, while addressing clinical applications of MSCs in lung cancer treatment.

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了解间充质干细胞在肺癌中的作用的进展

肺癌是全世界最常见和最致命的癌症类型。近几十年来，关于肺癌的研究取得了长足的进步，但肺癌仍然是恶性肿瘤相关死亡率的主要原因。间充质干细胞（MSCs）主要存在于脂肪、脐带血、骨髓、骨骼和肌肉中。MSC 是肿瘤微环境 (TME) 的主要组成部分。最近的研究表明，间充质干细胞在肺癌相关的增殖、侵袭、迁移和血管生成中发挥作用，但其潜在机制知之甚少。由于 MSCs 可以迁移到 TME，因此人们越来越关注在药物或基因载体中使用 MSCs 进行癌症治疗。本综述总结了间充质干细胞在肺癌中的作用和作用，同时阐述了间充质干细胞在肺癌治疗中的临床应用。