Introduction: The delivery of cell therapies may be an important frontier to treat different respiratory diseases in the near future. However, the cell size, delivery conditions, cell viability, and effect in the pulmonary function are critical factors. We performed a proof-of-concept experiment using ex vivo lungs and novel subglottic airway device that allows for selective lobar isolation and administration of drugs and biologics in liquid solution deep into the lung tissues, while simultaneously ventilating the rest of the lung lobes.

中文翻译：

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机械通气体外肺模型中干细胞选择性肺叶递送的正电子发射断层扫描-计算机断层扫描成像

简介：在不久的将来，细胞疗法可能成为治疗不同呼吸系统疾病的重要前沿领域。然而，细胞大小、分娩条件、细胞活力和对肺功能的影响是关键因素。我们使用体外肺和新型声门下气道装置进行了概念验证实验，该装置允许选择性肺叶分离和药物和生物制剂在液体溶液中深入肺组织，同时对其余肺叶进行通气。