ABSTRACT

Purpose

BMP-8a is a member of bone morphogenetic proteins (BMPs) and plays a regulatory role in human growth and development as a transcription regulator. This review aims to summarize the current research on the impact and mechanism of BMP-8a in female and male reproduction, formation and eruption of teeth, bone and cartilage development, tissue differentiation, disease occurrence, progression and prognosis.

Methods

The phrases “BMP-8a,” “BMPs,” “regulator,” “mechanism,” “osteoblast,” “cartilage,” “cancer,” “disease,” and “inflammation” were searched in the PubMed database. The abstracts were evaluated, and a series of original publications and reviews were examined.

Results

According to the search, BMP-8a affects the development of the uterus by inhibiting luteinization and plays an important role in late spermatogenesis. It is highly expressed in osteogenesis and differentially expressed in chondrogenesis. Furthermore, BMP-8a has a significant impact on the occurrence, development and prognosis of various diseases.

Conclusions

BMP-8a regulates important factors and pathways, such as SMAD2/3 and SMAD1/5/8, to promote or inhibit the developmental processes of human reproductive organs. BMP-8a is also a member of the BMP family of proteins that regulates chondrogenesis and osteogenesis. In addition to its osteoinductive capabilities, BMP-8a is involved in the progression of diverse cancers.

中文翻译：

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BMP-8a的生物学和生理学研究进展

摘要

目的

BMP-8a是骨形态发生蛋白(bone morphogenetic proteins, BMPs)的一员，作为转录调节剂在人体生长发育中发挥调节作用。本文旨在就BMP-8a在女性和男性生殖、牙齿形成和萌出、骨和软骨发育、组织分化、疾病发生、进展和预后中的影响和机制进行综述。

方法

在 PubMed 数据库中搜索了短语“BMP-8a”、“BMPs”、“调节器”、“机制”、“成骨细胞”、“软骨”、“癌症”、“疾病”和“炎症”。对摘要进行了评估，并检查了一系列原始出版物和评论。

结果

经查，BMP-8a通过抑制黄体化影响子宫发育，在晚期精子发生中起重要作用。它在成骨过程中高度表达，在软骨形成过程中差异表达。此外，BMP-8a对多种疾病的发生、发展和预后具有重要影响。

结论

BMP-8a调节重要的因子和通路，如SMAD2/3和SMAD1/5/8，以促进或抑制人类生殖器官的发育过程。BMP-8a 也是调节软骨形成和成骨的 BMP 蛋白家族的成员。除了其骨诱导能力外，BMP-8a 还参与多种癌症的进展。