Interaction between Pavlovian and instrumental control systems is key for adaptive motivated behavior, but also plays an important role in various neuropsychiatric disorders, including depression, addiction, and anxiety. Here, we employed the flouorodopa positron emission tomography ([¹⁸F]-DOPA PET) in healthy participants (N = 100) to assess whether dopamine synthesis capacity (Ki), specifically in the ventral striatum, accounts for individual variation in Pavlovian-to-instrumental transfer (PIT). Surprisingly, this was not the case. Rather, the relationship of ventral striatal Ki with PIT depended on working memory (WM) capacity. Ventral striatal dopamine boosted the effects of Pavlovian cues on instrumental responding to a greater degree in participants with higher WM capacity. Caution is warranted to interpret this post hoc four-way interaction given the modest sample size. Nonetheless, these results chime with prior findings demonstrating that dopaminergic drugs boost Pavlovian biases to a greater degree in participants with greater WM capacity and highlight the importance of interactions between striatal dopamine and WM capacity. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

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纹状体多巴胺对巴甫洛夫偏倚的影响。一项大型 [¹⁸F]-DOPA PET 研究。

巴甫洛夫和仪器控制系统之间的相互作用是适应性动机行为的关键，但也在各种神经精神疾病中发挥重要作用，包括抑郁、成瘾和焦虑。在这里，我们在健康参与者 (N = 100) 中采用了氟多巴正电子发射断层扫描 ([¹⁸F]-DOPA PET) 来评估多巴胺合成能力 (Ki)，特别是在腹侧纹状体中，是否解释了巴甫洛夫到-仪器转移（PIT）。令人惊讶的是，事实并非如此。相反，腹侧纹状体 Ki 与 PIT 的关系取决于工作记忆 (WM) 容量。腹侧纹状体多巴胺增强了巴甫洛夫线索对具有更高 WM 能力的参与者更大程度的乐器反应的影响。鉴于样本量适中，有必要谨慎解释这种事后四向相互作用。尽管如此，这些结果与之前的研究结果一致，表明多巴胺能药物在 WM 能力更强的参与者中更大程度地促进了巴甫洛夫偏倚，并强调了纹状体多巴胺和 WM 能力之间相互作用的重要性。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。