Introduction: Asthma is related to neurochemical alterations which affect brain functions and lead to anxiety and cognitive dysfunctions. Myrtenol has sparked considerable interest due to its pharmacological effects, especially for the remediation of chronic disorders. Thus, the present research was designed to evaluate the impacts of myrtenol on anxiety-like behaviors, cognitive declines, inflammation, and oxidative stress in the hippocampus of asthmatic rats. Methods: Rats were allocated to five groups: control, asthma, asthma/vehicle, asthma/myrtenol, and asthma/budesonide. Asthma was elicited in the rats by ovalbumin, and the animals were then exposed to myrtenol inhalation. Anxiety-like behavior and memory were assessed by elevated plus maze (EPM) and novel object and location recognition tests. Interleukins (interleukin-6, -17, and -10), tumor necrosis factor α (TNF-α), and oxidative stress biomarkers such as malondialdehyde (MDA), superoxide dismutase (SOD), Glutathione peroxidase (GPX), and total antioxidant capacity (TAC) in the hippocampus were assessed by the ELISA method. Results: The levels of IL-6, IL-17, TNF-α, and MDA decreased, but GPX, SOD, and TAC levels increased in the hippocampus of asthmatic animals due to myrtenol inhalation. Conclusion: Myrtenol diminished asthma-induced anxiety-like behaviors and cognitive deficits in asthmatic rats; these effects might have been typically mediated by a reduction in inflammation and oxidative stress.
Neuroimmunomodulation

中文翻译：

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Myrtenol 通过减轻大鼠的海马炎症和氧化应激来改善哮喘引起的识别记忆损伤和焦虑样行为

简介：哮喘与影响大脑功能并导致焦虑和认知功能障碍的神经化学改变有关。Myrtenol 由于其药理作用引起了人们的极大兴趣，特别是对于慢性疾病的治疗。因此，本研究旨在评估桃金娘醇对哮喘大鼠海马体的焦虑样行为、认知能力下降、炎症和氧化应激的影响。方法：大鼠被分配到五组：对照组、哮喘组、哮喘组/载体组、哮喘组/桃金娘烯醇组和哮喘组/布地奈德组。卵清蛋白在大鼠中引发哮喘，然后将动物吸入桃金娘醇。通过高架十字迷宫 (EPM) 和新的物体和位置识别测试评估类似焦虑的行为和记忆。白介素（白介素 6、-17 和 -10）、肿瘤坏死因子 α (TNF-α) 和氧化应激生物标志物，例如丙二醛 (MDA)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GPX) 和总抗氧化剂通过 ELISA 方法评估海马体容量 (TAC)。结果：由于吸入桃金娘醇，哮喘动物海马中 IL-6、IL-17、TNF-α 和 MDA 水平降低，但 GPX、SOD 和 TAC 水平升高。结论：Myrtenol 减少了哮喘大鼠的哮喘诱发的焦虑样行为和认知缺陷；这些影响通常可能是通过减少炎症和氧化应激来介导的。
神经免疫调节