Alcohol expectancies (AEs) are associated with likelihood of alcohol initiation and subsequent alcohol use disorders. It is unclear whether genetic predisposition to alcohol use and/or related traits contributes to shaping how one expects to feel when drinking alcohol. We used the Adolescent Brain Cognitive Development study to examine associations between genetic propensities (i.e., polygenic risk for problematic alcohol use, depression, risk-taking), sociodemographic factors (i.e., parent income), and the immediate social environment (i.e., peer use and disapproval toward alcohol) and positive and negative AEs in alcohol-naïve children (max analytic N = 5,352). Mixed-effect regression models showed that age, parental education, importance of the child’s religious beliefs, adverse childhood experiences, and peer disapproval of alcohol use were associated with positive and/or negative AEs, to varying degrees. Overall, our results suggest several familial and psychosocial predictors of AEs but little evidence of contributions from polygenic liability to problematic alcohol use or related phenotypes.

酒精预期 (AE) 与开始饮酒和随后饮酒障碍的可能性有关。目前尚不清楚饮酒的遗传倾向和/或相关特征是否有助于塑造一个人的预期感受喝酒时。我们使用青少年大脑认知发展研究来检查遗传倾向（即有问题的饮酒、抑郁、冒险的多基因风险）、社会人口因素（即父母收入）和直接社会环境（即同伴使用）之间的关联和不赞成酒精）以及未接触过酒精的儿童中的正面和负面 AE（最大分析 N = 5,352）。混合效应回归模型表明，年龄、父母教育、儿童宗教信仰的重要性、不良的童年经历和同伴对饮酒的反对在不同程度上与阳性和/或阴性 AE 相关。全面的，