ABSTRACT

Background

Fear of relapse into psychosis is an independent risk factor for future relapse events, indicating its importance as a novel intervention target.

Methods

Twenty-five participants responded to daily ecological momentary assessment prompts assessing common early warning signs of relapse and self-reported positive experiences like feeling supported by others. We conducted multilevel vector auto-regression using common symptoms assessed in early warning signs monitoring relapse prevention while controlling for positive self-reported experiences like feeling supported by others to estimate three networks (to explore concurrent, temporal and overall relationships).

Results

Reporting fear of relapse was positively associated (within the same cross-sectional time window) with hearing voices, alongside anxiety, negative affect and sleep change. Fear of relapse appeared to predict anxiety, negative affect and greater fear of relapse on the next consecutive day. However, none of the typical early warning signs predicted fear of relapse within the temporal window, and the observed relationships were small.

Discussion

Early warning signs appeared to be poor predictors of experiencing fear of relapse in this study. Fear of relapse predicts later anxiety and negative affect and may be a valuable intervention target within the daily life of people diagnosed with schizophrenia.

中文翻译：

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害怕精神病复发：使用每天一次的电子自我报告探索与常见的复发早期预警信号的动态关系

摘要

背景

对精神病复发的恐惧是未来复发事件的独立危险因素，表明其作为新干预目标的重要性。

方法

25 名参与者对每日生态瞬时评估提示作出回应，评估复发的常见早期预警信号和自我报告的积极体验，如感觉得到他人支持。我们使用在监测复发预防的早期预警信号中评估的常见症状进行多级向量自回归，同时控制积极的自我报告体验，如感觉得到他人支持，以估计三个网络（探索并发、暂时和整体关系）。

结果

报告对复发的恐惧与听到声音、焦虑、负面影响和睡眠变化呈正相关（在同一横截面时间窗内）。对复发的恐惧似乎预示着焦虑、负面情绪和对第二天连续复发的更大恐惧。然而，没有任何典型的早期预警信号预测在时间窗口内对复发的恐惧，并且观察到的关系很小。

讨论

在这项研究中，早期预警信号似乎不能很好地预测对复发的恐惧。对复发的恐惧预示着以后的焦虑和负面影响，并且可能是被诊断患有精神分裂症的人日常生活中有价值的干预目标。