Production cross sections of light positron emitters ¹¹C (t_1/2=20.36 min), ¹³N (t_1/2=9.97 min) and ¹⁵O (t_1/2=122 s) have been measured for proton-induced reactions on the main relevant constituents of the human body (C, N and O) from threshold up to 200 MeV of proton incident energy. This has been accomplished by means of two complementary experiments at the clinical proton treatment centers WPE (Essen) and HIT (Heidelberg), both in Germany. In the first case, the multi-foil activation technique was combined with PET imaging, a methodology previously developed at CNA (Seville, Spain). In the second experiment, aimed at energies below 50 MeV, the activation of single foils was measured with conventional LaBr₃ detectors. In both cases the IAEA monitor reaction ^natCu(p,x)⁶³Zn data was used for validation purposes.

The most complete and accurate set of excitation functions for the production of light-positron emitters ¹¹C, ¹³N and ¹⁵O in proton induced reactions on human tissue up to 200 MeV is presented. These data are needed for nuclear reaction model development and are extremely important to improve the accuracy of the PET range verification in proton radiotherapy. Seven excitation functions have been measured: ¹²C(p,x)¹¹C, ¹⁴N(p,x)¹¹C, ¹⁴N(p,x)¹³N, ¹⁴N(p,γ)¹⁵O, ¹⁶O(p,x)¹¹C, ¹⁶O(p,x)¹³N and ¹⁶O(p,x)¹⁵O up to 200 MeV of proton incident energy.

光正电子发射器的生产截面¹¹ C (t _{1 / 2} =20.36 min), ¹³ N (t _{1 / 2} =9.97 min) 和¹⁵ O (t _{1 / 2}=122 s) 已经测量了人体主要相关成分（C、N 和 O）的质子诱导反应，从阈值到 200 MeV 的质子入射能量。这是通过在德国 WPE（埃森）和 HIT（海德堡）临床质子治疗中心进行的两项互补实验实现的。在第一个案例中，多箔激活技术与 PET 成像相结合，这是一种先前在 CNA（西班牙塞维利亚）开发的方法。在第二个实验中，针对低于 50 MeV 的能量，使用传统的 LaBr ₃检测器测量了单箔的活化。在这两种情况下，IAEA 监测反应^nat Cu(p,x) ⁶³ Zn 数据都用于验证目的。

介绍了用于在高达 200 MeV 的人体组织质子诱导反应中产生光正电子发射器¹¹ C、¹³ N 和¹⁵ O的最完整和最准确的激发函数集。这些数据是核反应模型开发所必需的，对于提高质子放射治疗中 PET 射程验证的准确性极为重要。测量了七个激励函数：¹² C(p,x) ¹¹ C、¹⁴ N(p,x) ¹¹ C、¹⁴ N(p,x) ¹³ N、¹⁴ N(p, γ ) ¹⁵ O、¹⁶ O( p,x) ¹¹ C,¹⁶ O(p,x) ¹³ N 和¹⁶ O(p,x) ¹⁵ O 质子入射能量高达 200 MeV。