Background and Aims. Helicobacter pylori (H. pylori) and nonalcoholic fatty liver disease (NAFLD) have become increasingly recognized, both of which affect human health globally. The association of H. pylori infection with NAFLD remains unclear. Methods. PubMed, EMBASE, and Cochrane Library databases were searched. Only a random-effects model was used. Odds ratios (ORs) and risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for the combined estimates of raw data. Adjusted ORs (aORs) and hazard ratios (aHRs) with 95% CIs were calculated for the combined estimates of data adjusted for confounders. Results. Thirty-four studies with 218573 participants were included. Based on unadjusted data from 26 cross-sectional studies and 3 case-control studies, H. pylori infection was significantly associated with the presence of NAFLD (OR = 1.26, 95% CI = 1.17–1.36, ). Based on adjusted data from 15 cross-sectional studies and 1 case-control study, H. pylori infection was significantly associated with the presence of NAFLD (aOR = 1.25, 95% CI = 1.08–1.44, ). Compared with control subjects without NAFLD, patients with moderate (OR = 1.67, 95% CI = 1.17–2.39, ) and severe (OR = 1.71, 95% CI = 1.30–2.24, ) NAFLD, but not those with mild NAFLD (OR = 1.14, 95% CI = 0.9–1.45, ), had significantly higher proportions of H. pylori infection. The association of H. pylori infection with the occurrence of NAFLD was statistically significant based on adjusted data from 3 cohort studies (aHR = 1.18, 95% CI = 1.05–1.34, ), but not based on unadjusted data from 3 cohort studies (RR = 1.41, 95% CI = 0.80–2.48, ). Conclusion. H. pylori infection is associated with NAFLD, especially moderate and severe NAFLD. The impact of H. pylori eradication on the prevention of NAFLD should be further explored.

中文翻译：

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幽门螺杆菌感染与非酒精性脂肪肝的关系：一项荟萃分析

背景和目标。幽门螺杆菌( H. pylori ) 和非酒精性脂肪性肝病 (NAFLD) 已得到越来越多的认可，这两种疾病都会影响全球人类健康。幽门螺杆菌感染与 NAFLD的关联仍不清楚。方法。搜索了 PubMed、EMBASE 和 Cochrane 图书馆数据库。仅使用随机效应模型。优势比 (OR) 和风险比 (RR) 以及 95% 置信区间 (CI) 被计算用于原始数据的组合估计。调整后的 OR (aOR) 和风险比 (aHR) 与 95% CI 被计算为针对混杂因素调整的数据的综合估计。结果. 纳入了 34 项研究，共有 218573 名参与者。根据来自 26 项横断面研究和 3 项病例对照研究的未经调整的数据，幽门螺杆菌感染与 NAFLD 的存在显着相关（OR = 1.26，95% CI = 1.17–1.36，). 根据 15 项横断面研究和 1 项病例对照研究的调整数据，幽门螺杆菌感染与 NAFLD 的存在显着相关（aOR = 1.25，95% CI = 1.08–1.44，). 与没有 NAFLD 的对照组相比，中度患者 (OR = 1.67, 95% CI = 1.17–2.39,)和重度 (OR = 1.71, 95% CI = 1.30–2.24,) NAFLD，但不是那些轻度 NAFLD (OR = 1.14, 95% CI = 0.9–1.45,),有显着更高的H. 幽门传染的比例。根据 3 项队列研究的校正数据，幽门螺杆菌感染与 NAFLD 发生的关联具有统计学意义（aHR = 1.18，95% CI = 1.05–1.34，)，但不是基于 3 项队列研究的未经调整的数据（RR = 1.41，95% CI = 0.80–2.48，). 结论。幽门螺杆菌感染与NAFLD相关，尤其是中度和重度NAFLD。应进一步探讨根除幽门螺杆菌对预防 NAFLD的影响