Phytoestrogens are known to have beneficial properties in various carcinomas. They exhibit its efficacy at cellular levels. Naringenin a flavonoidal phytoestrogen is been explored for its antioxidant, cardio protective and cytotoxic function. The low absorbtion and poor bioavailability of naringenin makes it less efficient in targeting tumours at cellular levels. Due to the structural similarity of naringenin with estradiol and considering the affinity of naringenin with estrogen receptor, this study explores the interactions of naringenin on important signaling proteins involved in ER positive breast cancer through molecular docking studies and the prepared naringenin solid lipid nano particles were characterized and studied for its preventive potential against breast cancer cell lines. The lipidoid form of phytoestrogen shows promising cytotoxic potential compared with naringenin.

中文翻译：

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柚皮素及其纳米结构脂质载体在 ERα 阳性乳腺癌中的分子对接和细胞毒性相互作用

已知植物雌激素在各种癌症中具有有益的特性。它们在细胞水平上表现出功效。柚皮素是一种黄酮类植物雌激素，其抗氧化、心脏保护和细胞毒性功能已被探索。柚皮素的低吸收和低生物利用度使其在细胞水平上靶向肿瘤的效率较低。由于柚皮素与雌二醇结构相似，考虑到柚皮素与雌激素受体的亲和性，本研究通过分子对接研究柚皮素与ER阳性乳腺癌相关重要信号蛋白的相互作用，并对制备的柚皮素固体脂质纳米颗粒进行了表征。并研究了它对乳腺癌细胞系的预防潜力。