Psoriasis is a chronic, mild and common inflammatory skin condition. Still an ideal treatment for psoriasis, effective, safe, convenient, and economical is not available. In this scenario, the search for suitable alternative treatments with minimal side effects is necessary. Plants can be effective and alternative in this regard. Therefore, this article discusses the leaves of the plants Thespesia populnea (Malvaceae) that are traditionally used in the treatment of psoriasis. The present study aimed to assess anti-psoriatic activity. The dried leaves of the plants were subjected to soxhlation with 95% ethanol and phytochemical studies were performed. The anti-psoriatic activity was evaluated by the Mouse-Tail model. It is a relatively sensitive and reproducible morphometric method that allows quantitative evaluation of the effects of anti-psoriatics through epidermal differentiation. Extracts were applied topically at a dose of 500mg/kg over 14 days and at the end, the animals were sacrificed, longitudinal histological sections were made of the tail skin and the degree of orthokeratosis was determined. It was significantly (P <0.05) increased by the ethanolic extract of Thespesia populnea (52.86±2.86) compared to the control (17.30±4.09). In relative epidermal thickness, the ethanolic extract of Thespesia populnea (92.68±8.8) showed a significant difference (P <0.05) compared to the control (100±10.7). The data obtained suggest that the selected plant has anti-psoriatic activity and confirms its traditional use in the treatment of psoriasis.

中文翻译：

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Thespesia populnea 叶乙醇提取物的植物化学评价和抗银屑病活性

牛皮癣是一种慢性、轻微且常见的炎症性皮肤病。目前尚无有效、安全、方便、经济的银屑病理想治疗方法。在这种情况下，有必要寻找副作用最小的合适替代疗法。植物在这方面可以是有效的和替代的。因此，本文讨论了传统上用于治疗牛皮癣的植物 Thespesia populnea（锦葵科）的叶子。本研究旨在评估抗银屑病活性。将植物的干燥叶子用 95% 乙醇进行熏蒸，并进行植物化学研究。通过鼠尾模型评估抗银屑病活性。它是一种相对敏感且可重复的形态测定方法，可以通过表皮分化定量评估抗银屑病药物的作用。在 14 天内以 500mg/kg 的剂量局部应用​​提取物，最后处死动物，对尾部皮肤进行纵向组织切片，并确定正角化程度。与对照 (17.30±4.09) 相比，白杨乙醇提取物 (52.86±2.86) 显着 (P <0.05) 增加。在相对表皮厚度方面，白杨乙醇提取物（92.68±8.8）与对照（100±10.7）相比显示出显着差异（P <0.05）。获得的数据表明，所选植物具有抗牛皮癣活性，并证实了其在牛皮癣治疗中的传统用途。