Michael Eugene Doyle, Ana Marina Ferreira and colleagues review the current understanding of bone tissue mineralisation and structure, providing a critical outlook on the existing biomimetic strategies of mineralising collagen for bone tissue engineering applications. Featured on the cover is a scanning electron microscopy image of in vitro biomineralised collagen with biomimetic matrix density. The biomimetic collagenous matrix was mineralised (in absence of cells) through the liquid coprecipitation of apatite and collagen, and subsequently densified through plastic compression. The fabricated woven fibrillar matrix boasts extensive extra-fibrillar mineralisation and clusters of carbonated hydroxyapatite crystals dispersed throughout. DOI: 10.1002/bip.23527

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Michael Eugene Doyle、Ana Marina Ferreira 及其同事回顾了目前对骨组织矿化和结构的理解，对用于骨组织工程应用的矿化胶原蛋白的现有仿生策略提出了重要展望。封面特色是具有仿生基质密度的体外生物矿化胶原蛋白的扫描电子显微镜图像。仿生胶原基质通过磷灰石和胶原蛋白的液体共沉淀被矿化（在没有细胞的情况下），随后通过塑性压缩被致密化。制造的编织纤维基质具有广泛的纤维外矿化和分散在各处的碳酸化羟基磷灰石晶体簇。DOI: 10.1002/bip.23527