Summary

Bronchopulmonary dysplasia [BPD] is the most common complication of extremely preterm delivery and its optimal management remains challenging because of a lack of evidence to guide management. There has been improvement in the management of evolving BPD in the neonatal intensive care unit (NICU). The threshold for provision of home oxygen therapy, often occurring because of a preference for earlier discharge from the NICU, creates tensions for clincians and families. Once discharged in supplemental oxygen, the approaches for the weaning of this therapy vary considerably across the world. Regardless of guidelines and multidisciplinary team support, up to a third of families of an infant with BPD elect to withdraw home oxygen therapy independently of medical advice. There is a pressing need to derive evidence to better inform practice, generate international consensus and undertake large, appropriately funded, longitudinal studies of BPD with clinically meaningful outcomes (respiratory, cardiovascular and neurodevelopmental) from infancy to adulthood.

中文翻译：

---

在家吸氧的支气管肺发育不良婴儿：缺乏充分证据的断奶难题

概括

支气管肺发育不良[BPD] 是极早产最常见的并发症，由于缺乏指导治疗的证据，其最佳治疗仍然具有挑战性。新生儿重症监护病房(NICU)对不断发展的 BPD 的管理有所改善。提供家庭氧疗的门槛通常是因为人们希望尽早从新生儿重症监护病房出院，这给临床医生和家属带来了紧张气氛。一旦在补充氧气中出院，世界各地的撤除这种疗法的方法差异很大。无论指南和多学科团队的支持如何，多达三分之一的 BPD 婴儿家庭选择不顾医疗建议而停止家庭氧疗。迫切需要获取证据以更好地为实践提供信息，形成国际共识，并进行大规模、适当资助的 BPD 纵向研究，从婴儿期到成年期产生具有临床意义的结果（呼吸、心血管和神经发育）。