Abstract

Objective

Partial nephrectomy is the gold standard treatment in small renal tumours. During partial nephrectomy, the renal artery is clamped which creates transient ischemia. This can damage nephrons and may affect kidney function immediately postoperatively and on long-term.

In the present study, we investigated the effect of ischemia time during partial nephrectomy with regards to affection of renal function immediately post-operatively and 1-year post-surgery.

Materials and method

A retrospective cohort study including 124 patients who underwent partial nephrectomy at a single regional hospital in the period from 2018 to 2020 was conducted.

Results

We divided patients into subgroups based on the ischemia time: [0–8], [9–13] and [14–29] minutes. The mean value for kidney function was an eGFR (mL/min) of 73.9 before and 66.8 at a 12-month post-surgery. We found no significant correlation between ischemia time and renal function. Noticeably, none of the patients had ischemia time greater than 30 min.

Conclusion

In this cohort, the duration of ischemia time was not associated with differences in renal affection neither on short term nor long term parameters if the ischemia time was kept below 30 min.

中文翻译：

---

肾部分切除术中缺血时间对短期和长期肾功能的影响

摘要

客观的

肾部分切除术是治疗小肾肿瘤的金标准。在部分肾切除术中，肾动脉被夹住，造成短暂性缺血。这会损害肾单位，并可能在术后即刻和长期影响肾功能。

在本研究中，我们调查了肾部分切除术期间缺血时间对术后即刻和术后 1 年肾功能影响的影响。

材料与方法

进行了一项回顾性队列研究，包括 2018 年至 2020 年期间在一家地区医院接受部分肾切除术的 124 名患者。

结果

我们根据缺血时间将患者分成亚组：[0-8]、[9-13] 和 [14-29] 分钟。肾功能的平均值为 eGFR（mL/min），术前为 73.9，术后 12 个月为 66.8。我们发现缺血时间和肾功能之间没有显着相关性。值得注意的是，没有患者的缺血时间超过 30 分钟。

结论

在这个队列中，如果缺血时间保持在 30 分钟以下，那么无论是短期参数还是长期参数，缺血时间的持续时间都与肾脏影响的差异无关。