Killer-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses. NK cells are the first responders in the face of infection and help promote placentation during pregnancy; the importance of KIRs in these NK-mediated processes is well-established. However, mounting evidence suggests that KIRs also have a prominent and long-lasting effect on the adaptive immune system. Here, we review the evidence for the impact of KIRs on T cell responses with a focus on the clinical significance of this interaction.

中文翻译：

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先天受体调节适应性 T 细胞反应：KIR-HLA 相互作用和 T 细胞介导的慢性病毒感染控制

杀伤细胞免疫球蛋白样受体（KIR）主要在自然杀伤（NK）细胞上表达，是先天免疫反应的关键调节因子。NK细胞是面对感染的第一反应者，有助于促进怀孕期间的胎盘形成；KIR 在这些 NK 介导的过程中的重要性是众所周知的。然而，越来越多的证据表明，KIR 对适应性免疫系统也具有显着且持久的影响。在这里，我们回顾了 KIR 对 T 细胞反应影响的证据，重点关注这种相互作用的临床意义。