In the decade since non-invasive prenatal testing (NIPT) was first implemented as a prenatal screening tool, it has gained recognition for its sensitivity and specificity in the detection of common aneuploidies. This review mainly focuses on the emerging role of NIPT in pregnancies following assisted reproductive technology (ART) in the light of current evidence and recommendations. It also deals with the challenges, shortcomings and interpretational difficulties related to NIPT in ART pregnancies, with particular emphasis on twin and vanishing twin pregnancies, which are widely regarded as the Achilles’ heel of most pre-natal screening platforms. Future directions for exploration towards improving the performance and extending the scope of NIPT are also addressed.

中文翻译：

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辅助生殖后妊娠的无创产前检测

自从无创产前检测 (NIPT) 首次作为产前筛查工具实施以来的十年间，它因其在检测常见非整倍体方面的敏感性和特异性而获得认可。根据当前的证据和建议，本综述主要关注 NIPT 在辅助生殖技术 (ART) 后妊娠中的新兴作用。它还处理了 ART 妊娠中与 NIPT 相关的挑战、缺点和解释困难，特别强调双胞胎和消失的双胞胎妊娠，这被广泛认为是大多数产前筛查平台的致命弱点。还讨论了提高 NIPT 性能和扩展 NIPT 范围的未来探索方向。