Abstract

Background

Irisin was found to correlate with coronary artery disease (CAD) in diabetic patients. This study investigated the association of irisin and FNDC5 (SNP rs3480) with the presence and severity of CAD in T2DM.

Methods

This cross-sectional study included 100 patients with T2DM divided into two groups, DM group (n = 50), including patients without CAD and CAD group (n = 50), including those confirmed to have CAD by coronary angiography. Irisin was measured. SNP rs3480 genotyping of FNDC5 was done.

Results

Irisin levels were significantly lower in the CAD group (p < 0.001). The CAD group had significantly higher HbA1c and lower HDL (p < 0.001). Patients with controlled DM had significantly higher irisin levels (p < 0.001). single nucleotide polymorphism (SNP) rs3480 was not associated with irisin levels, and the FNDC5 rs3480 AA reference allele was significantly associated with significant CAD.

Conclusion

Irisin appears to be protective against developing CAD in diabetic patients. Irisin level was an independent predictor of significant CAD in diabetic patients combined with the FNDC5 rs3480 genotype.

Clinical trial registration number

NCT04957823

中文翻译：

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合并和不合并 CAD 的 2 型糖尿病患者的 Irisin 表达和 FNDC5 (rs3480) 基因多态性

摘要

背景

发现鸢尾素与糖尿病患者的冠状动脉疾病 (CAD) 相关。本研究调查了鸢尾素和FNDC5 (SNP rs3480) 与 T2DM 中 CAD 的存在和严重程度之间的关联。

方法

这项横断面研究包括 100 名 T2DM 患者，分为两组，DM 组（n  = 50），包括无 CAD 患者和 CAD 组（n  = 50），包括经冠状动脉造影证实患有 CAD 的患者。测量了鸢尾素。完成了FNDC5的 SNP rs3480 基因分型。

结果

CAD 组的鸢尾素水平显着降低 ( p  < 0.001)。CAD 组的 HbA1c 显着升高，HDL 显着降低 ( p  < 0.001)。DM 受控患者的鸢尾素水平显着升高 ( p  < 0.001)。单核苷酸多态性 (SNP) rs3480 与鸢尾素水平无关，而FNDC5 rs3480 AA 参考等位基因与显着 CAD 显着相关。

结论

鸢尾素似乎可以防止糖尿病患者发生 CAD。鸢尾素水平是合并FNDC5 rs3480 基因型的糖尿病患者显着 CAD 的独立预测因子。

临床试验注册号

NCT04957823