Long non-coding RNAs (lncRNAs) are more than 200 bp in length and do not translate into functional proteins. They are involved in inhibiting cell growth, migration, and invasion, and in promoting apoptosis. It was found that cancer-related LINC00961 is downregulated in a variety of malignant tumors, including lung cancer, renal cell carcinoma, and hepatocellular carcinoma. LINC00961 either inhibits or promotes the expression of many genes to affect cancer progression via microRNAs such as miR-5581-3p, miR-367, miR-223-3p, miR-19-3p, and miR-125b-5p, epithelial–mesenchymal transition, and Wnt/β-catenin signaling pathway. Thus, LINC00961 may be a viable biomarker or therapeutic target for human cancers. In this review, we summarize the current evidence of the biological functions of LINC00961 in tumor development, to provide new insights and ideas for molecular targeted therapy for patients with cancer.

Abbreviations: CRLS1, cardiolipin synthase 1; EMT, epithelial–mesenchymal transformation; HCC, hepatocellular carcinoma; LncRNA, long non-coding RNA; LUAD, lung adenocarcinoma; NSCLC, non-small cell lung cancer; OSCC, oral squamous cell carcinoma; PCAN, proliferating cell nuclear antigen; PTEN, phosphatase and tensin homologue; RCC, renal cell carcinoma; SPAR, small regulatory polypeptide of amino acid response; TSCC, tongue squamous cell carcinoma; VSMCs, vascular smooth muscle cell.

长链非编码 RNA (lncRNA) 的长度超过 200 bp，不会转化为功能性蛋白质。它们参与抑制细胞生长、迁移和侵袭，并促进细胞凋亡。研究发现，与癌症相关的 LINC00961 在多种恶性肿瘤中表达下调，包括肺癌、肾细胞癌和肝细胞癌。LINC00961 抑制或促进许多基因的表达，通过 miR-5581-3p、miR-367、miR-223-3p、miR-19-3p 和 miR-125b-5p、上皮-间充质转换和 Wnt/β-catenin 信号通路。因此，LINC00961 可能是人类癌症的可行生物标志物或治疗靶点。在这篇综述中，我们总结了 LINC00961 在肿瘤发展中的生物学功能的当前证据，

缩写：CRLS1，心磷脂合酶 1；EMT，上皮-间质转化；HCC，肝细胞癌；LncRNA，长链非编码RNA；LUAD，肺腺癌；NSCLC，非小细胞肺癌；OSCC，口腔鳞状细胞癌；PCAN，增殖细胞核抗原；PTEN，磷酸酶和张力蛋白同系物；RCC，肾细胞癌；SPAR，氨基酸反应的小调节多肽；TSCC，舌鳞状细胞癌；VSMCs，血管平滑肌细胞。