Hypoxia-induced neonatal seizure (HINS) is associated with cognitive disorders in later life. Since the neuroinflammation following HINS leads to these deleterious effects, in the current study, the short-term outcomes of Fingolimod (FTY720) treatment as an anti-inflammatory agent was investigated in the rat model of HINS. Seizures were induced in postnatal day (P10) by exposure to 5 % O₂ for 15 min. Forty-five minutes after the onset of hypoxia, pups received FTY720 (0.3 mg/kg) or normal saline for 12 consecutive days. Then, behavioral functions of the rats were assessed by commonly used tests. Subsequently, hippocampal tissue sampling at P22-P23 was done for biochemical assessments and real-time PCR. The results showed that FTY720 prevents cognitive impairments and related reduction of malondialehyde (MDA) concentration in the hippocampus of both male and female hypoxic animals. Furthermore, FTY720 administration following HINS could not prevent the decreased brain-derived neurotrophic factor (BDNF) concentration, increased nitric oxide (NO) level and decreased Interleukin-4 (IL-4) gene expression in the hippocampus of both male and female hypoxic animals. Interestingly, FTY720 showed significant interaction with sex in hippocampal Tumor necrosis factor alpha (TNF-α) gene expression and BDNF concentration. Taken together, these results suggest that FTY720 administration in the lactation period can prevent the deleterious effects of HINS on cognition in later life by ameliorating inflammation and oxidative stress in the hippocampus of both male and female juvenile rats.

缺氧引起的新生儿惊厥 (HINS) 与晚年的认知障碍有关。由于 HINS 后的神经炎症会导致这些有害影响，因此在当前的研究中，在 HINS 大鼠模型中研究了芬戈莫德 (FTY720) 作为抗炎剂治疗的短期结果。_{通过暴露于 5 % O 2}在产后一天 (P10) 诱发癫痫发作15分钟。缺氧开始后 45 分钟，幼崽连续 12 天接受 FTY720（0.3 mg/kg）或生理盐水。然后，通过常用测试评估大鼠的行为功能。随后，对 P22-P23 的海马组织取样进行生化评估和实时 PCR。结果表明，FTY720 可防止雄性和雌性缺氧动物海马体中的认知障碍和相关的丙二醛 (MDA) 浓度降低。此外，在 HINS 后施用 FTY720 不能阻止雄性和雌性缺氧动物海马中脑源性神经营养因子 (BDNF) 浓度降低、一氧化氮 (NO) 水平升高和白细胞介素 4 (IL-4) 基因表达降低. 有趣的是，FTY720 在海马肿瘤坏死因子 α (TNF-α) 基因表达和 BDNF 浓度中显示出与性别的显着相互作用。总之，这些结果表明，在哺乳期给予 FTY720 可以通过改善雄性和雌性幼年大鼠海马体的炎症和氧化应激来预防 HINS 对晚年认知的有害影响。