This study tested whether multiple domains of social adversity, including neighborhood opportunity/deprivation and life stress, moderate genetic (A), common environmental (C), and unique environmental (E) influences on externalizing behaviors in 760 same-sex twin pairs (332 monozygotic; 428 dizygotic) ages 10–11 from the ABCD Study. Proportion of C influences on externalizing behavior increased at higher neighborhood adversity (lower overall opportunity). A decreased and C and E increased at lower levels of educational opportunity. A increased at lower health-environment and social-economic opportunity levels. For life stress, A decreased and E increased with number of experienced events. Results for educational opportunity and stressful life experiences suggest a bioecological gene-environment interaction pattern such that environmental influences predominate at higher levels of adversity, whereas limited access to healthcare, housing, and employment stability may potentiate genetic liability for externalizing behavior via a diathesis-stress mechanism. More detailed operationalization of social adversity in gene-environment interaction studies is needed.

本研究测试了社会逆境的多个领域，包括邻里机会/剥夺和生活压力、中等遗传 ( A )、共同环境 ( C ) 和独特环境 ( E ) 是否对 760 对同性双胞胎的外化行为产生影响 (332 ABCD 研究中 10-11 岁的同卵双胞胎；428 名双卵双胞胎。在邻里逆境较高（整体机会较低）时，C对外化行为的影响比例会增加。在教育机会水平较低的情况下，A减少，C和E增加。在较低的健康环境和社会经济机会水平下增加。对于生活压力，随着经历事件的数量的增加， A减少，E增加。教育机会和压力生活经历的结果表明生物生态基因-环境相互作用模式，使得环境影响在较高水平的逆境中占主导地位，而获得医疗保健、住房和就业稳定性的机会有限可能会通过素质压力增强外化行为的遗传倾向机制。需要在基因-环境相互作用研究中对社会逆境进行更详细的操作。