Background. Essential hypertension is the result of modifiable and genetic factors, and it is associated with increased risk for atherothrombosis. Some polymorphisms are associated with hypertensive disease. The objective was to analyze the association between eNOS Glu298Asp, MTHR C677T, AGT M235T, AGT T174M, and A1166C and ACE I/D polymorphisms with essential hypertension in the Mexican population. Materials and Methods. In the present study, 224 patients with essential hypertension and 208 subjects without hypertension were included. The Glu298Asp, C677T, M235T, T174M, A1166C, and I/D polymorphisms were determined by the PCR-RFLP technique. Results. We found statistical differences in age, gender, BMI, systolic and diastolic blood pressure, and total cholesterol between control and cases. However, we found no significant differences in HbA1c and triglycerides between both groups. We observed statistical significant differences in the genotype distribution of Glu298Asp (), I/D (), and M235T () polymorphisms between both groups. In contrast, there were no differences related to distribution of genotypes of MTHFR C677T (), M174T (), and A1166C () between cases and control groups. Conclusions. We identified that Glu298Asp, I/D, and M234T polymorphisms represented an increased risk for essential hypertension and those genetic variants could contribute to the presence of endothelial dysfunction and vasopressor effect, hyperplasia, and hypertrophy of smooth muscle cells, which had an impact for hypertension. In contrast, we found no association between C677C, M174T, and A1166C polymorphisms and hypertensive disease. We suggested that those genetic variants could be identified in individuals with high risk to avoid hypertension and thrombotic disease.

中文翻译：

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肾素-血管紧张素系统和 eNOS Glu298Asp 基因的多态性与墨西哥人群患原发性高血压的风险增加有关

背景。原发性高血压是可改变和遗传因素的结果，它与动脉粥样硬化血栓形成的风险增加有关。一些多态性与高血压疾病有关。目的是分析墨西哥人群中 eNOS Glu298Asp、MTHR C677T、AGT M235T、AGT T174M 和 A1166C 和 ACE I/D 多态性与原发性高血压之间的关联。材料和方法。在本研究中，包括 224 名原发性高血压患者和 208 名无高血压患者。Glu298Asp、C677T、M235T、T174M、A1166C 和 I/D 多态性通过 PCR-RFLP 技术确定。结果. 我们发现对照组和病例组在年龄、性别、BMI、收缩压和舒张压以及总胆固醇方面存在统计学差异。然而，我们发现两组之间的 HbA1c 和甘油三酯没有显着差异。我们观察到 Glu298Asp 的基因型分布存在统计学显着差异（), I/D (),和 M235T ()两组之间的多态性。相比之下，MTHFR C677T 的基因型分布没有差异（), M174T (),和 A1166C ()病例和对照组之间。结论。我们发现 Glu298Asp、I/D 和 M234T 多态性代表原发性高血压的风险增加，这些遗传变异可能导致内皮功能障碍和血管加压效应、增生和平滑肌细胞肥大的存在，这对高血压有影响. 相反，我们发现 C677C、M174T 和 A1166C 多态性与高血压疾病之间没有关联。我们建议可以在高风险个体中识别这些遗传变异，以避免高血压和血栓性疾病。