Granular cell tumor (GCT) was first described by Abrikossoff in 1926. It is a mostly benign tumor with rare malignant transformation. It is defined as a soft tissue neoplasm with abundant eosinophilic cytoplasm. The mean age of diagnosis for GCT is around 45 years. It is rare for GCT to be found in the gastrointestinal (GI) tract. Within the subset of GI tract, the colon is an extremely rare site for it to be found. Franburg-Smith histopathology criteria are used to differentiate a benign from a malignant GCT. The malignant form is aggressive with high recurrence rates after resection. Histopathology and immunohistochemical stains are used to make a definitive diagnosis. Herein, we present a rare case of an ascending colon polyp that was resected and found to be a benign GCT.
Case Rep Gastroenterol 2023;17:104–108

中文翻译：

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升结肠颗粒细胞瘤

颗粒细胞瘤(granular cell tumor, GCT)于1926年由Abrikossoff首先描述。它是一种以良性为主的肿瘤，很少恶变。它被定义为具有丰富嗜酸性细胞质的软组织肿瘤。GCT 的平均诊断年龄约为 45 岁。GCT 很少见于胃肠道 (GI)。在胃肠道的子集中，结肠是一个极其罕见的部位。Franburg-Smith 组织病理学标准用于区分良性和恶性 GCT。恶性形式具有侵袭性，切除后复发率高。组织病理学和免疫组织化学染色用于做出明确诊断。在此，我们介绍一例罕见的升结肠息肉切除后发现是良性 GCT。
案例代表 Gastroenterol 2023；17:104–108