The onset and development of periodontitis centers around microbiota dysbiosis and disrupted host responses. Dynamic metabolic activities of the subgingival microbiota modify the polymicrobial community, shape the microenvironment, and modulate the host response. A complicated metabolic network exists in interspecies interactions between periodontal pathobionts and commensals, which can lead to the development of dysbiotic plaque. Dysbiotic subgingival microbiota undergo metabolic interactions with the host and disrupt host–microbe equilibrium. In this review, we discuss the metabolic profiles of the subgingival microbiota, the metabolic crosstalk in polymicrobial communities, including pathobionts and commensals, and the metabolic interactions between microbes and the host.

中文翻译：

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牙周致病菌的代谢：它们在失调菌群中的调节作用

牙周炎的发生和发展以微生物群失调和宿主反应紊乱为中心。龈下微生物群的动态代谢活动改变了多种微生物群落，塑造了微环境，并调节了宿主反应。牙周致病菌和共生菌之间的种间相互作用存在复杂的代谢网络，可导致菌斑的形成。失调的龈下微生物群会与宿主发生代谢相互作用并破坏宿主-微生物平衡。在这篇综述中，我们讨论了龈下微生物群的代谢概况、多微生物群落中的代谢串扰，包括致病菌和共生菌，以及微生物与宿主之间的代谢相互作用。