Objective: To determine whether statin medication in individuals with obesity, dyslipidemia, and metabolic syndrome affects their capacity to mobilize and oxidize fat during exercise. Methods: Twelve individuals with metabolic syndrome pedaled during 75 min at 54 ± 13% ${\dot{\mathrm{V}}\mathrm{O}}_2\text{max}$ (5.7 ± 0.5 metabolic equivalents) while taking statins (STATs) or after 96-hr statin withdrawal (PLAC) in a randomized double-blind fashion. Results: At rest, PLAC increased low-density lipoprotein cholesterol (i.e., STAT 2.55 ± 0.96 vs. PLAC 3.16 ± 0.76 mmol/L; p = .004) and total cholesterol blood levels (i.e., STAT 4.39 ± 1.16 vs. PLAC 4.98 ± 0.97 mmol/L; p = .008). At rest, fat oxidation (0.99 ± 0.34 vs. 0.76 ± 0.37 μmol·kg⁻¹·min⁻¹ for STAT vs. PLAC; p = .068) and the rates of plasma appearance of glucose and glycerol (i.e., Ra glucose–glycerol) were not affected by PLAC. After 70 min of exercise, fat oxidation was similar between trials (2.94 ± 1.56 vs. 3.06 ± 1.94 μmol·kg⁻¹·min⁻¹, STA vs. PLAC; p = .875). PLAC did not alter the rates of disappearance of glucose in plasma during exercise (i.e., 23.9 ± 6.9 vs. 24.5 ± 8.2 μmol·kg⁻¹·min⁻¹ for STAT vs. PLAC; p = .611) or the rate of plasma appearance of glycerol (i.e., 8.5 ± 1.9 vs. 7.9 ± 1.8 μmol·kg⁻¹·min⁻¹ for STAT vs. PLAC; p = .262). Conclusions: In patients with obesity, dyslipidemia, and metabolic syndrome, statins do not compromise their ability to mobilize and oxidize fat at rest or during prolonged, moderately intense exercise (i.e., equivalent to brisk walking). In these patients, the combination of statins and exercise could help to better manage their dyslipidemia.

目的：确定肥胖、血脂异常和代谢综合征患者服用他汀类药物是否会影响他们在运动过程中动员和氧化脂肪的能力。方法： 12 名患有代谢综合征的人在 75 分钟内以 54 ± 13% 的速度踩踏板${\dot{\mathrm{V}}\mathrm{欧}}_{\mathrm{2个}}\text{最大限度}$（5.7 ± 0.5 代谢当量）同时服用他汀类药物 (STATs) 或在 96 小时他汀类药物停药后 (PLAC) 以随机双盲方式。结果：在休息时，PLAC 增加了低密度脂蛋白胆固醇（即 STAT 2.55 ± 0.96 对比 PLAC 3.16 ± 0.76 mmol/L；p = .004）和 总胆固醇血液水平（即 STAT 4.39 ± 1.16 对比 PLAC 4.98 ± 0.97 毫摩尔/升；p  = .008)。静止时，脂肪氧化（0.99 ± 0.34 对比 0.76 ± 0.37 μmol·kg ⁻¹ ·min ⁻¹对于 STAT 对比 PLAC；p = .068) 以及葡萄糖和甘油（即 Ra 葡萄糖-甘油）的血浆出现率不受 PLAC 的影响。运动 70 分钟后，试验之间的脂肪氧化相似（2.94 ± 1.56 与 3.06 ± 1.94 μmol·kg ^-1 ·min ^-1，STA 与 PLAC；p  = .875）。PLAC 不改变运动期间血浆中葡萄糖消失的速率（即 23.9 ± 6.9 对 24.5 ± 8.2 μmol·kg ⁻¹ ·min ⁻¹对于 STAT 与 PLAC；p  = .611）或血浆速率甘油的出现（即 8.5 ± 1.9 与 7.9 ± 1.8 μmol·kg ^-1 ·min ^-1对于 STAT 与 PLAC；p  = .262）。结论：对于患有肥胖症、血脂异常和代谢综合征的患者，他汀类药物不会损害他们在休息时或长时间中等强度运动（即相当于快走）时动员和氧化脂肪的能力。在这些患者中，他汀类药物和运动的结合可以帮助更好地控制他们的血脂异常。