Regenerative endodontic procedures (REPs) are a research hotspot in the endodontic field. One of the biggest problems of REPs is that it is difficult to realize regeneration of pulp-dentin complex and functional reconstruction. The reason is still not clear. We hypothesize that the migration may be different in different dental stem cells. Periodontal ligament stem cells (PDLSCs) may migrate faster than stem cells of apical papilla (SCAPs), differentiating into cementum-like tissue, bone-like tissue and periodontal ligament-like tissue and, finally affecting the outcomes of REPs. Hence, this study aimed to explore the mechanism that regulates the migration of PDLSCs.

中文翻译：

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SDF-1α-CXCR4/CXCR7 在人牙周膜干细胞迁移中的作用。

再生牙髓治疗（REPs）是牙髓治疗领域的研究热点。REPs最大的问题之一是难以实现牙髓-牙本质复合体的再生和功能重建。原因还不清楚。我们假设迁移在不同的牙科干细胞中可能不同。牙周膜干细胞 (PDLSCs) 可能比根尖乳头干细胞 (SCAPs) 迁移得更快，分化为牙骨质样组织、骨样组织和牙周膜样组织，并最终影响 REPs 的结果。因此，本研究旨在探索调节PDLSCs迁移的机制。