Cellular reprogramming in regenerative medicine holds great promise for treating patients with neurological disorders. In this regard, small molecule-mediated cellular conversion has attracted special attention because of its ease of reproducibility, applicability, and fewer safety concerns. However, currently available protocols for the direct conversion of somatic cells to neurons are limited in clinical application due of their complex nature, lengthy process, and low conversion efficiency.

中文翻译：

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表观遗传调控因子在人成纤维细胞高效神经元重编程中的战略应用。

再生医学中的细胞重编程为治疗神经系统疾病患者带来了巨大希望。在这方面，小分子介导的细胞转化因其易于重现性、适用性和较少的安全问题而受到特别关注。然而，目前可用的将体细胞直接转化为神经元的方案由于其复杂的性质、漫长的过程和低的转化效率而在临床应用中受到限制。