Binge eating is a persistent behavior associated with a chronic course of illness and poor treatment outcomes. While clinical research is unable to capture the full course of binge eating, preclinical approaches offer the opportunity to examine binge-like eating from onset through chronic durations, allowing identification of factors contributing to binge eating persistence. The present study quantified the trajectories of binge-like eating onset and modeled cycles of abstinence/relapse to develop a translational model for binge eating persistence. Adult male and female C57Bl6/J mice were randomized to a binge-like palatable food access schedule (daily 2-hr, 3×/week) or continuous, nonbinge like palatable food access for 12 days (Experiment 1). Persistence of palatable food consumption in both binge-like palatable food access groups was then examined across three cycles of forced abstinence and reexposure to palatable food (incubation) to model the persistence of binge eating in clinical populations. Mice with daily 2-hr palatable food access escalated their intake more than mice in the 3×/week or continuous groups (Experiment 1). This pattern was more pronounced in females. In addition, this pattern of palatable food intake reemerged across multiple cycles of behavioral incubation (Experiment 2). These findings provide a model of binge-like eating in mice that can be used in future studies examining both environmental factors and neural mechanisms contributing to binge eating persistence. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

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检查间歇性可口食物暴露后小鼠暴饮暴食行为的发作轨迹和持续性。

暴饮暴食是一种与慢性病程和不良治疗结果相关的持续行为。虽然临床研究无法捕捉暴食的整个过程，但临床前方法提供了检查暴食从发作到长期持续时间的机会，从而可以识别导致暴食持续的因素。本研究量化了暴食发作的轨迹，并对禁食/复发的周期进行了建模，以开发暴食持续性的转化模型。成年雄性和雌性 C57Bl6/J 小鼠被随机分配至暴饮暴食型可口食物获取计划（每天 2 小时，3 次/周）或连续非暴饮暴食型可口食物获取方案 12 天（实验 1）。然后，在强制禁欲和重新接触可口食物（孵化）的三个周期中检查两个暴饮暴食可口食物获取组中可口食物消耗的持续性，以模拟临床人群中暴食的持续性。每天 2 小时获取可口食物的小鼠比每周 3 次或连续组的小鼠摄入量增加更多（实验 1）。这种模式在女性中更为明显。此外，这种可口食物摄入模式在行为孵化的多个周期中重新出现（实验 2）。这些发现提供了小鼠暴饮暴食的模型，可用于未来研究导致暴食持续性的环境因素和神经机制。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。